chronic alcoholics . chlormethiazole infusion in Cardiac arrest following
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چکیده
Introduction Chlormethiazole is a sedative and hypnotic with marked anti-convulsant properties. It is widely used in the treatment of states characterized by convulsions and agitation, including delirium tremens. Although rarely causing side effects, the drug has been shown to depress the respiratory centre (Lechat, 1966) and toxic interactions with alcohol have been found in animals (Vapaatalo and Karppanen, 1969). Sudden deaths ascribed to chlormethiazole therapy have been attributed to respiratory depression, and alcohol abuse seems to be a predisposing factor (Pentikainen, Valtonen and Miettinen, 1976). Two cases are reported where cardiac arrest, without evidence of preceding respiratory depression, followed chlormethiazole infusion in the treatment of delirium tremens.
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تاریخ انتشار 2008